Rice seed for delivery of vaccines to gut mucosal immune tissues
نویسندگان
چکیده
منابع مشابه
Mucosal delivery of vaccines in domestic animals.
Mucosal vaccination is proving to be one of the greatest challenges in modern vaccine development. Although highly beneficial for achieving protective immunity, the induction of mucosal immunity, especially in the gastro-intestinal tract, still remains a difficult task. As a result, only very few mucosal vaccines are commercially available for domestic animals. Here, we critically review variou...
متن کاملSublingual Delivery of Vaccines for the Induction of Mucosal Immunity
The mucosal surfaces are constantly exposed to incoming pathogens which can cause infections that result in severe morbidity and/or mortality. Studies have reported that mucosal immunity is important for providing protection against these pathogens and that mucosal vaccination is effective in preventing local infections. For many years, the sublingual mucosa has been targeted to deliver immunot...
متن کاملHistamine and gut mucosal immune regulation.
Histamine is a biogenic amine with extensive effects on many cell types, mediated by the activation of its four receptors (H1R-H4R). Distinct effects are dependent on receptor subtypes and their differential expression. Within the gastrointestinal tract, histamine is present at relatively high concentrations, particularly during inflammatory responses. In this review, we discuss the immunoregul...
متن کاملMucosal immune responses to meningococcal conjugate polysaccharide vaccines in infants.
BACKGROUND Serogroup C meningococcal conjugate polysaccharide vaccines have been reported to induce significant serum IgG antibodies and immunologic memory in infants. Because meningococcus is a mucosal pathogen colonizing the nasopharynx, local mucosal immune responses may play an important role in host defense against infection and carriage. We have investigated the mucosal IgA and IgG antibo...
متن کاملThe role of gut-associated lymphoid tissues and mucosal defence.
The newborn infant leaves a germ-free intrauterine environment to enter a contaminated extrauterine world and must have adequate intestinal defences to prevent the expression of clinical gastrointestinal disease states. Although the intestinal mucosal immune system is fully developed after a full-term birth, the actual protective function of the gut requires the microbial stimulation of initial...
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ژورنال
عنوان ژورنال: Plant Biotechnology Journal
سال: 2015
ISSN: 1467-7644
DOI: 10.1111/pbi.12423